Endocrine Abstracts

The fertility is commonly impaired in acromegalic patients; therefore, pregnancy in acromegaly is relatively a rare event. Little is known about management of pregnant acromegalic patients and the out come of their pregnancies. This is a report of a rather unusual case of a 37-year-old acromegalic lady diagnosed in 2001. Transphenoidal surgery 2002 continued having GH IGF1A so who had two successful pregnancies in spite her active disease. She was diagnosed in 2002 after a cli...

61 years old female with multiple comorbidities such as ckd-3, Trans abdominal hysterectomy and oophorectomy for endometrial cancer, complicated by entero-cutaneous fistula, ileal conduit and cholecystectomy.She presented with generally unwell, nausea, vomiting, confusion.On Examination she was bradycardic, low gcs, hypotensive and hypothermic.The metabolic causes for confusion was excluded, anion gap was nor...

A 44-year-old lady with hypertension and type 2 diabetes of 10 years duration (BMI 47, HbA1c 9.1%) treated with metformin and exenatide presented with a few days history of feeling generally unwell, vomiting and confusion. Initial examination showed pulse 120 per min, BP 115/74 mmHg, normal temperature and multiple abdominal striae. Admission investigations showed Na 140, K 1.4, urea 3.9, creatinine 74, glucose 26, CRP 23 Hb 16.2, WBC 11.6. ABGS on room air showed pH 7.41, PCO...

Congenital adrenal hyperplasia (CAH) is a group a rare autosomal recessive disorders characterised by a deficiency on one of the enzymes necessary for cortisol biosynthesis. More than 90% of CAH is caused by mutations or deletions in cytochrome P450 21-hydroxylase gene. Impaired glucocorticoid synthesis results in chronic elevation of ACTH causing adrenal hyperplasia and accumulation of steroid precursors such as 17-hydroxyprogesterone (17-HOP). The main goal in CAH managemeng...

Background: The management of Cushing’s disease can be challenging especially when patients can present with sepsis and severely immunocompromised with limited oral medications to achieve cortisol control. We review a case of Cushing’s disease and the medical management of Cushing’s disease.Case Report: A 54 year old female presented with symptomatic hyperglycaemia with truncal obesity, proximal muscle weakness, right posterior thorax haem...